Document 0063
 DOCN  M9490063
 TI    Necrotizing ulcerative periodontitis: a marker for immune deterioration
       and a predictor for the diagnosis of AIDS.
 DT    9411
 AU    Glick M; Muzyka BC; Salkin LM; Lurie D; University of Pennsylvania
       School of Dental Medicine,; Philadelphia.
 SO    J Periodontol. 1994 May;65(5):393-7. Unique Identifier : AIDSLINE
       MED/94322163
 AB    A multitude of oral lesions have been described in individuals infected
       with the human immunodeficiency virus (HIV). Few studies have attempted
       to correlate specific oral findings with immune status and HIV disease
       progression in the population reflecting the demographic profile of this
       epidemic. A prospective study was conducted among 700 ambulatory
       HIV-infected individuals seeking dental care between July 1, 1988 and
       June 30, 1992. Patients entered the study when they first applied for
       care and were followed at regular intervals unless death occurred before
       the conclusion of the study. The prevalence rate of necrotizing
       ulcerative periodontitis (NUP) was calculated for the entire population
       and specific to race, gender, and HIV transmission category. Survival
       analysis was used to estimate the cumulative probability of death within
       24 months of a NUP diagnosis. The association between NUP diagnosis and
       CD4+ cell count below 200 cells/mm3 was also investigated, and it was
       found that HIV-infected individuals presenting with a diagnosis of NUP
       were 20.8 times as likely to have a CD4+ cell count below 200 cells/mm3
       compared to HIV-infected individuals presenting without NUP. The
       prevalence of NUP was 6.3%. The lesion was significantly more common
       among men having sex with men (MSM), 8.4%, compared with non-MSM males,
       1.8%. No racial difference was noted. The mean CD4+ cell count for
       patients with NUP was 51.8 cells/mm3 (SD +/- 71.2) while the median CD4+
       cell count was 32.0 cells/mm3. The predictive value of a CD4+ cell count
       below 200 cells/mm3 in patients with this lesion was 95.1%. A cumulative
       probability of death within 24 months of a NUP diagnosis was
       72.9%.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adult  Female  Gingivitis, Necrotizing Ulcerative/ETHNOLOGY/*IMMUNOLOGY
       Human  HIV Infections/COMPLICATIONS/*DIAGNOSIS  Leukocyte Count  Life
       Tables  Male  Periodontitis/ETHNOLOGY/*IMMUNOLOGY  Prognosis
       Prospective Studies  T4 Lymphocytes  JOURNAL ARTICLE

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